Mal-PEG1-Val-Cit-PAB-PNP

Name: Mal-PEG1-Val-Cit-PAB-PNP
Brand: MedChemExpress
SKU: HY-140144
Rating: 4.5 (1 reviews)

Cat. No.: HY-140144 Purity: 98.41%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-PEG1-Val-Cit-PAB-PNP Chemical Structure

CAS No. : 2249935-92-8

Size	Price	Stock	Quantity
5 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 405	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

739.73

Formula

C₃₄H₄₁N₇O₁₂

CAS No.

2249935-92-8

Appearance

Solid

Color

White to off-white

SMILES

O=[N+]([O-])C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCN3C(C=CC3=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (168.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3518 mL	6.7592 mL	13.5184 mL
5 mM	0.2704 mL	1.3518 mL	2.7037 mL
10 mM	0.1352 mL	0.6759 mL	1.3518 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.41%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (252 KB) HNMR (330 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3518 mL	6.7592 mL	13.5184 mL	33.7961 mL
	5 mM	0.2704 mL	1.3518 mL	2.7037 mL	6.7592 mL
	10 mM	0.1352 mL	0.6759 mL	1.3518 mL	3.3796 mL
	15 mM	0.0901 mL	0.4506 mL	0.9012 mL	2.2531 mL
	20 mM	0.0676 mL	0.3380 mL	0.6759 mL	1.6898 mL
	25 mM	0.0541 mL	0.2704 mL	0.5407 mL	1.3518 mL
	30 mM	0.0451 mL	0.2253 mL	0.4506 mL	1.1265 mL
	40 mM	0.0338 mL	0.1690 mL	0.3380 mL	0.8449 mL
	50 mM	0.0270 mL	0.1352 mL	0.2704 mL	0.6759 mL
	60 mM	0.0225 mL	0.1127 mL	0.2253 mL	0.5633 mL
	80 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.4225 mL
	100 mM	0.0135 mL	0.0676 mL	0.1352 mL	0.3380 mL