2. PROTAC
  3. PROTAC Linkers
  4. Mal-PEG2-oxyamine

Mal-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Mal-PEG2-oxyamine TFA) that retains the same biological activity.

For research use only. We do not sell to patients.

Mal-PEG2-oxyamine Chemical Structure

Mal-PEG2-oxyamine Chemical Structure

CAS No. : 1146245-73-9

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5 mg USD 160 Ask For Quote & Lead Time
10 mg USD 260 Ask For Quote & Lead Time

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Other Forms of Mal-PEG2-oxyamine:

Mal-PEG2-oxyamine Related Antibodies

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Description

Mal-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-PEG2-oxyamine Related Antibodies
Molecular Weight

244.24

Formula

C10H16N2O5
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

NOCCOCCOCCN1C(C=CC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (204.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0943 mL 20.4717 mL 40.9433 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0943 mL 20.4717 mL 40.9433 mL 102.3583 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL 20.4717 mL
10 mM 0.4094 mL 2.0472 mL 4.0943 mL 10.2358 mL
15 mM 0.2730 mL 1.3648 mL 2.7296 mL 6.8239 mL
20 mM 0.2047 mL 1.0236 mL 2.0472 mL 5.1179 mL
25 mM 0.1638 mL 0.8189 mL 1.6377 mL 4.0943 mL
30 mM 0.1365 mL 0.6824 mL 1.3648 mL 3.4119 mL
40 mM 0.1024 mL 0.5118 mL 1.0236 mL 2.5590 mL
50 mM 0.0819 mL 0.4094 mL 0.8189 mL 2.0472 mL
60 mM 0.0682 mL 0.3412 mL 0.6824 mL 1.7060 mL
80 mM 0.0512 mL 0.2559 mL 0.5118 mL 1.2795 mL
100 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0236 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mal-PEG2-oxyamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG2-oxyamine1146245-73-9PROTAC LinkersInhibitorinhibitorinhibit

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