Mal-PEG2-Val-Cit-PAB-OH

Name: Mal-PEG2-Val-Cit-PAB-OH
Brand: MedChemExpress
SKU: HY-130222
Rating: 4.5 (1 reviews)

Cat. No.: HY-130222 Purity: 99.49%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-PEG2-Val-Cit-PAB-OH Chemical Structure

CAS No. : 2055041-38-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
Customer Review

Description

IC₅₀ & Target

Cleavable Linker

Protease Cleavable Linker

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

618.68

Formula

C₂₉H₄₂N₆O₉

CAS No.

2055041-38-6

Appearance

Solid

Color

White to off-white

SMILES

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN2C(C=CC2=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (202.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6163 mL	8.0817 mL	16.1634 mL
5 mM	0.3233 mL	1.6163 mL	3.2327 mL
10 mM	0.1616 mL	0.8082 mL	1.6163 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.49%

Select Batch:

Data Sheet (242 KB) SDS (393 KB)

COA (246 KB) HNMR (366 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6163 mL	8.0817 mL	16.1634 mL	40.4086 mL
	5 mM	0.3233 mL	1.6163 mL	3.2327 mL	8.0817 mL
	10 mM	0.1616 mL	0.8082 mL	1.6163 mL	4.0409 mL
	15 mM	0.1078 mL	0.5388 mL	1.0776 mL	2.6939 mL
	20 mM	0.0808 mL	0.4041 mL	0.8082 mL	2.0204 mL
	25 mM	0.0647 mL	0.3233 mL	0.6465 mL	1.6163 mL
	30 mM	0.0539 mL	0.2694 mL	0.5388 mL	1.3470 mL
	40 mM	0.0404 mL	0.2020 mL	0.4041 mL	1.0102 mL
	50 mM	0.0323 mL	0.1616 mL	0.3233 mL	0.8082 mL
	60 mM	0.0269 mL	0.1347 mL	0.2694 mL	0.6735 mL
	80 mM	0.0202 mL	0.1010 mL	0.2020 mL	0.5051 mL
	100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.4041 mL