Mal-PEG2-Val-Cit-PABA

Name: Mal-PEG2-Val-Cit-PABA
Brand: MedChemExpress
SKU: HY-145489
Rating: 4.5 (1 reviews)

Cat. No.: HY-145489 Purity: 98.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-PEG2-Val-Cit-PABA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-PEG2-Val-Cit-PABA Chemical Structure

CAS No. : 1662687-83-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-PEG2-Val-Cit-PABA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

590.63

Formula

C₂₇H₃₈N₆O₉

CAS No.

1662687-83-3

Appearance

Solid

Color

White to off-white

SMILES

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OCCOCCN2C(C=CC2=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (211.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6931 mL	8.4655 mL	16.9311 mL
5 mM	0.3386 mL	1.6931 mL	3.3862 mL
10 mM	0.1693 mL	0.8466 mL	1.6931 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.91%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (247 KB) HNMR (284 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6931 mL	8.4655 mL	16.9311 mL	42.3277 mL
	5 mM	0.3386 mL	1.6931 mL	3.3862 mL	8.4655 mL
	10 mM	0.1693 mL	0.8466 mL	1.6931 mL	4.2328 mL
	15 mM	0.1129 mL	0.5644 mL	1.1287 mL	2.8218 mL
	20 mM	0.0847 mL	0.4233 mL	0.8466 mL	2.1164 mL
	25 mM	0.0677 mL	0.3386 mL	0.6772 mL	1.6931 mL
	30 mM	0.0564 mL	0.2822 mL	0.5644 mL	1.4109 mL
	40 mM	0.0423 mL	0.2116 mL	0.4233 mL	1.0582 mL
	50 mM	0.0339 mL	0.1693 mL	0.3386 mL	0.8466 mL
	60 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.7055 mL
	80 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.5291 mL
	100 mM	0.0169 mL	0.0847 mL	0.1693 mL	0.4233 mL