2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Mal-PEG8-Val-Cit-PAB-MMAE

Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162).

For research use only. We do not sell to patients.

Mal-PEG8-Val-Cit-PAB-MMAE Chemical Structure

Mal-PEG8-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 2353409-69-3

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1 mg USD 320 In-stock
5 mg USD 930 In-stock
10 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

Mal-PEG8-Val-Cit-PAB-MMAE Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162)[1].

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-PEG8-Val-Cit-PAB-MMAE Related Antibodies
Molecular Weight

1626.97

Formula

C81H131N11O23
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (67.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6146 mL 3.0732 mL 6.1464 mL
5 mM 0.1229 mL 0.6146 mL 1.2293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6146 mL 3.0732 mL 6.1464 mL 15.3660 mL
5 mM 0.1229 mL 0.6146 mL 1.2293 mL 3.0732 mL
10 mM 0.0615 mL 0.3073 mL 0.6146 mL 1.5366 mL
15 mM 0.0410 mL 0.2049 mL 0.4098 mL 1.0244 mL
20 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.7683 mL
25 mM 0.0246 mL 0.1229 mL 0.2459 mL 0.6146 mL
30 mM 0.0205 mL 0.1024 mL 0.2049 mL 0.5122 mL
40 mM 0.0154 mL 0.0768 mL 0.1537 mL 0.3841 mL
50 mM 0.0123 mL 0.0615 mL 0.1229 mL 0.3073 mL
60 mM 0.0102 mL 0.0512 mL 0.1024 mL 0.2561 mL
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Mal-PEG8-Val-Cit-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG8-Val-Cit-PAB-MMAE2353409-69-3Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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