Mal-PEG8-Val-Cit-PAB-MMAE

Name: Mal-PEG8-Val-Cit-PAB-MMAE
Brand: MedChemExpress
SKU: HY-141156
Rating: 4.5 (1 reviews)

Cat. No.: HY-141156 Purity: 99.67%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162).

For research use only. We do not sell to patients.

Mal-PEG8-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 2353409-69-3

Size	Price	Stock	Quantity
1 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 930	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162)^[1].

IC₅₀ & Target

Auristatin

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1626.97

Formula

C₈₁H₁₃₁N₁₁O₂₃

CAS No.

2353409-69-3

Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 110 mg/mL (67.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6146 mL	3.0732 mL	6.1464 mL
5 mM	0.1229 mL	0.6146 mL	1.2293 mL
10 mM	0.0615 mL	0.3073 mL	0.6146 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.67%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (254 KB) HNMR (622 KB) RP-HPLC (237 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6146 mL	3.0732 mL	6.1464 mL	15.3660 mL
	5 mM	0.1229 mL	0.6146 mL	1.2293 mL	3.0732 mL
	10 mM	0.0615 mL	0.3073 mL	0.6146 mL	1.5366 mL
	15 mM	0.0410 mL	0.2049 mL	0.4098 mL	1.0244 mL
	20 mM	0.0307 mL	0.1537 mL	0.3073 mL	0.7683 mL
	25 mM	0.0246 mL	0.1229 mL	0.2459 mL	0.6146 mL
	30 mM	0.0205 mL	0.1024 mL	0.2049 mL	0.5122 mL
	40 mM	0.0154 mL	0.0768 mL	0.1537 mL	0.3841 mL
	50 mM	0.0123 mL	0.0615 mL	0.1229 mL	0.3073 mL
	60 mM	0.0102 mL	0.0512 mL	0.1024 mL	0.2561 mL