MAO A/HSP90-IN-1 

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC₅₀ value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research^[1].

MAO A/HSP90-IN-1 (4-b) (0.1 μM-3 μM, 24h) reduces the proliferation of GBM cells via inhibiting MAO A and HSP90^[1].
MAO A/HSP90-IN-1 (0.1 μM-3 μM, 24h) shows IC₅₀ 0.73 μM in GL26, 1.68 μM in U251S, and 0.84 μM in U251R^[1].
MAO A/HSP90-IN-1 (0μM, 0.35μM, 0.7μM, 1.4μM, 24h) inhibits IFN-_γ induced PD-L1 expression concentration-dependently in GL26 mouse GBM cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO A/HSP90-IN-1 (4-b) (25 mg/kg for intraperitoneal injection, once a day) shows significantly decreased tumor growth in GL26 GBM mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

444.95

C₂₄H₂₉ClN₂O₄

2927489-95-8

CN(C1=CC(Cl)=C(C=C1)OCCCN(CC#C)C)C(C2=C(C=C(C(C(C)C)=C2)O)O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tseng HJ, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. Eur J Med Chem. 2023 Aug 5;256:115459.  [Content Brief]