2. Neuronal Signaling Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Monoamine Oxidase HSP
  4. MAO A/HSP90-IN-1

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research.

For research use only. We do not sell to patients.

MAO A/HSP90-IN-1 Chemical Structure

MAO A/HSP90-IN-1 Chemical Structure

CAS No. : 2927489-95-8

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MAO A/HSP90-IN-1 Related Antibodies

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MAO-A MAO-B

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].

IC50 & Target[1]

HSP90

0.019 μM (IC50)

MAO-A

1.77 μM (IC50)

In Vitro

MAO A/HSP90-IN-1 (4-b) (0.1 μM-3 μM, 24h) reduces the proliferation of GBM cells via inhibiting MAO A and HSP90[1].
MAO A/HSP90-IN-1 (0.1 μM-3 μM, 24h) shows IC50 0.73 μM in GL26, 1.68 μM in U251S, and 0.84 μM in U251R[1].
MAO A/HSP90-IN-1 (0μM, 0.35μM, 0.7μM, 1.4μM, 24h) inhibits IFN-γ induced PD-L1 expression concentration-dependently in GL26 mouse GBM cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO A/HSP90-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: U87MG, U373MG, LN229, A172, T98G, P1S, P3, and P3R human GBM cells
Concentration: 50 μM
Incubation Time: 72 h
Result: Inhibited cell growth in GBM cell lines with an IC50 ratio was around 1 except A172 cell.

Western Blot Analysis[1]

Cell Line: GL26, U251R cells
Concentration: 3μM, 1μM, 0.3μM, 0.1μM
Incubation Time: 24 h
Result: Decreased the protein expression of HER2 and phospho-Akt in GL26 and U251R cell lines.
In Vivo

MAO A/HSP90-IN-1 (4-b) (25 mg/kg for intraperitoneal injection, once a day) shows significantly decreased tumor growth in GL26 GBM mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GL26 GBM mouse model[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Decreased tumor growth inhibition (TGI%) was 63.2% compared to vehicle group.
Molecular Weight

444.95

Formula

C24H29ClN2O4
CAS No.
SMILES

CN(C1=CC(Cl)=C(C=C1)OCCCN(CC#C)C)C(C2=C(C=C(C(C(C)C)=C2)O)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO A/HSP90-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO A/HSP90-IN-12927489-95-8Monoamine OxidaseHSPMAOHeat shock proteinsmonoamine oxidase Aheat shock protein 90PD-L1 expressionGlioblastomaInhibitorinhibitorinhibit

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