2. MAPK/ERK Pathway Immunology/Inflammation
  3. p38 MAPK Interleukin Related IRAK
  4. MAPK-IN-4

MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent. MAPK-IN-4 can inhibit the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS (HY-D1056). MAPK-IN-4 can bind to IRAK4 and exert its anti-inflammatory effect by inhibiting the MAPK pathway.

For research use only. We do not sell to patients.

MAPK-IN-4 Chemical Structure

MAPK-IN-4 Chemical Structure

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MAPK-IN-4 Related Antibodies

Top Publications Citing Use of Products

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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IRAK1 IRAK4

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Description

MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent. MAPK-IN-4 can inhibit the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS (HY-D1056). MAPK-IN-4 can bind to IRAK4 and exert its anti-inflammatory effect by inhibiting the MAPK pathway[1].

Molecular Weight

458.35

Formula

C22H24BrN3O3
SMILES

N[C@@H]1CC[C@H](OC2=C3C=C(OC)C(OCC4=CC=CC(Br)=C4)=CC3=NC=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAPK-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAPK-IN-4p38 MAPKInterleukin RelatedIRAKILInterleukin-1 receptor associated kinaseIL-1R associated kinaseRAW264.7J774A.1THP-1Cute Lung Injury ModelUlcerative Colitis ModelInhibitorinhibitorinhibit

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HY-172406
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