2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Margetuximab

Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer.

For research use only. We do not sell to patients.

CAS No. : 1350624-75-7

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Margetuximab Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric
IC50 & Target

EC50: 39.33 ng/mL (HER2)[1]
In Vitro

Margetuximab (MGAH22) enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Margetuximab Related Antibodies

Cell Proliferation Assay

Cell Line: JIMT-1, MCF-7, ZR-75-1, SKBR-3, HT-29, SW750 and N87[1]
Concentration: 0.001-1000 ng/mL
Incubation Time: 6 days
Result: Enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant.
In Vivo

Margetuximab (2-4 mg/kg; IP 5 or 6 times at weekly) can firstly and significantly reduces the tumor size at day 30 - 37 in mice model[1].
Margetuximab (15-150 mg/kg; IV; 6 weekly) exhibits well tolerated in cynomolgus monkeys, decreases NK cells by an average of 51%, and induces IL-6 release[1].
Margetuximab (50 mg/kg; IV; single dosage) exhibits favorable safety profile[1].
Pharmacokinetic Parameters of Margetuximab in cynomolgus monkeys[1].

Male, IV (50 mg/kg) Female, IV (50 mg/kg)
Cmax (mg/mL) 1.62 ± 0.10 1.70 ± 0.14
AUC0-￥ (mg·hour/mL) 294.1 ± 53.2 314.2 ± 31.3
T1/2β (days) 9.3 ± 1.8 9.7 ± 1.1
Clearance (mL/hour) 0.43 ± 0.07 0.40 ± 0.04
VSS (mL) 132 ± 2 127 ± 8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Margetuximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Margetuximab on AHC2 biosensor, can bind HER2/CD340 Protein, Human (HEK293, His, HY-P70254) with an affinity constant of 5.604E-10 M as determined in BLI assay.
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (232 KB) SDS-PAGE (123 KB) SEC-HPLC (170 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Margetuximab Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Margetuximab1350624-75-7EGFREpidermal growth factor receptorErbB-1HER1HER2JIMT-1Cynomolgus monkeysAnticancerMetastatic HER2-positive breast cancerInhibitorinhibitorinhibit

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