2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Margetuximab

Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer.

For research use only. We do not sell to patients.

CAS No. : 1350624-75-7

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Margetuximab Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric
IC50 & Target

EC50: 39.33 ng/mL (HER2)[1]
In Vitro

Margetuximab (MGAH22) enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Margetuximab Related Antibodies

Cell Proliferation Assay

Cell Line: JIMT-1, MCF-7, ZR-75-1, SKBR-3, HT-29, SW750 and N87[1]
Concentration: 0.001-1000 ng/mL
Incubation Time: 6 days
Result: Enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant.
In Vivo

Margetuximab (2-4 mg/kg; IP 5 or 6 times at weekly) can firstly and significantly reduces the tumor size at day 30 - 37 in mice model[1].
Margetuximab (15-150 mg/kg; IV; 6 weekly) exhibits well tolerated in cynomolgus monkeys, decreases NK cells by an average of 51%, and induces IL-6 release[1].
Margetuximab (50 mg/kg; IV; single dosage) exhibits favorable safety profile[1].
Pharmacokinetic Parameters of Margetuximab in cynomolgus monkeys[1].

Male, IV (50 mg/kg) Female, IV (50 mg/kg)
Cmax (mg/mL) 1.62 ± 0.10 1.70 ± 0.14
AUC0-￥ (mg·hour/mL) 294.1 ± 53.2 314.2 ± 31.3
T1/2β (days) 9.3 ± 1.8 9.7 ± 1.1
Clearance (mL/hour) 0.43 ± 0.07 0.40 ± 0.04
VSS (mL) 132 ± 2 127 ± 8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

146100.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Margetuximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Margetuximab on AHC2 biosensor, can bind HER2/CD340 Protein, Human (HEK293, His, HY-P70254) with an affinity constant of 5.604E-10 M as determined in BLI assay.
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (232 KB) SDS-PAGE (123 KB) SEC-HPLC (170 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Margetuximab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Margetuximab1350624-75-7EGFREpidermal growth factor receptorErbB-1HER1HER2JIMT-1Cynomolgus monkeysAnticancerMetastatic HER2-positive breast cancerInhibitorinhibitorinhibit

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