2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE 

Cat. No.: HY-147204 Purity: 98.26%
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Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) is a potent anticancer agent, which can be specific activated by tumor microenvironment. Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE can suppress tumor growth in mice (extracted from patent CN104147612A).

For research use only. We do not sell to patients.

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE Chemical Structure

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE Chemical Structure

CAS No. : 1638970-46-3

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1 mg USD 350 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE Related Antibodies

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Description

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) is a potent anticancer agent, which can be specific activated by tumor microenvironment. Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE can suppress tumor growth in mice (extracted from patent CN104147612A)[1].

In Vivo

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) (26.2 micro-rubbing/kg, IV, weekly for 4 weeks) suppresses tumor growth in mice bearing Panc-1 tumor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1316.58

Formula

C67H101N11O16
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](C(N[C@H](C)[C@H](C1=CC=CC=C1)O)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](C)NC(CCCCCN(C4=O)C(C=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 180 mg/mL (136.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7595 mL 3.7977 mL 7.5954 mL
5 mM 0.1519 mL 0.7595 mL 1.5191 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7595 mL 3.7977 mL 7.5954 mL 18.9886 mL
5 mM 0.1519 mL 0.7595 mL 1.5191 mL 3.7977 mL
10 mM 0.0760 mL 0.3798 mL 0.7595 mL 1.8989 mL
15 mM 0.0506 mL 0.2532 mL 0.5064 mL 1.2659 mL
20 mM 0.0380 mL 0.1899 mL 0.3798 mL 0.9494 mL
25 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7595 mL
30 mM 0.0253 mL 0.1266 mL 0.2532 mL 0.6330 mL
40 mM 0.0190 mL 0.0949 mL 0.1899 mL 0.4747 mL
50 mM 0.0152 mL 0.0760 mL 0.1519 mL 0.3798 mL
60 mM 0.0127 mL 0.0633 mL 0.1266 mL 0.3165 mL
80 mM 0.0095 mL 0.0475 mL 0.0949 mL 0.2374 mL
100 mM 0.0076 mL 0.0380 mL 0.0760 mL 0.1899 mL
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Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE1638970-46-3Drug-Linker Conjugates for ADCMDA-MB231Panc-1anticanceractivationconjugateInhibitorinhibitorinhibit

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