2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. MC-Val-Cit-PAB-MMAF

MC-Val-Cit-PAB-MMAF  (Synonyms: Vc-MMAF)

Cat. No.: HY-112786 Purity: 98.16%
SDS COA Handling Instructions

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MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity.

For research use only. We do not sell to patients.

MC-Val-Cit-PAB-MMAF Chemical Structure

MC-Val-Cit-PAB-MMAF Chemical Structure

CAS No. : 863971-17-9

Size Price Stock Quantity
1 mg USD 250 In-stock
5 mg USD 506 In-stock
10 mg USD 811 In-stock
25 mg USD 1460 In-stock
50 mg USD 2110 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

MC-Val-Cit-PAB-MMAF Related Antibodies

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Description

MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity[1].

IC50 & Target[1]

Auristatin

 

Molecular Weight

1330.61

Formula

C68H103N11O16
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3)=O)=O)=O)=O)OC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (75.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7515 mL 3.7577 mL 7.5153 mL
5 mM 0.1503 mL 0.7515 mL 1.5031 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.16%

SDS (252 KB)

COA (247 KB) LCMS (269 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7515 mL 3.7577 mL 7.5154 mL 18.7884 mL
5 mM 0.1503 mL 0.7515 mL 1.5031 mL 3.7577 mL
10 mM 0.0752 mL 0.3758 mL 0.7515 mL 1.8788 mL
15 mM 0.0501 mL 0.2505 mL 0.5010 mL 1.2526 mL
20 mM 0.0376 mL 0.1879 mL 0.3758 mL 0.9394 mL
25 mM 0.0301 mL 0.1503 mL 0.3006 mL 0.7515 mL
30 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6263 mL
40 mM 0.0188 mL 0.0939 mL 0.1879 mL 0.4697 mL
50 mM 0.0150 mL 0.0752 mL 0.1503 mL 0.3758 mL
60 mM 0.0125 mL 0.0626 mL 0.1253 mL 0.3131 mL
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MC-Val-Cit-PAB-MMAF Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Val-Cit-PAB-MMAF863971-17-9Vc-MMAFDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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