MC-VC-PAB-NH2 TFA

Cat. No.: HY-136132A Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

MC-VC-PAB-NH2 TFA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

MC-VC-PAB-NH2 TFA Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of MC-VC-PAB-NH2 TFA:

MC-VC-PAB-NH2 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MC-VC-PAB-NH2 TFA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

Molecular Weight

772.77

Formula

C₃₃H₄₇F₃N₈O₁₀

CAS No.

1616727-21-9

Appearance

Solid

Color

White to off-white

SMILES

OC(C(F)(F)F)=O.NCCNC(OCC1=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (323.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2940 mL	6.4702 mL	12.9405 mL
5 mM	0.2588 mL	1.2940 mL	2.5881 mL
10 mM	0.1294 mL	0.6470 mL	1.2940 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (247 KB) HNMR (338 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2940 mL	6.4702 mL	12.9405 mL	32.3512 mL
	5 mM	0.2588 mL	1.2940 mL	2.5881 mL	6.4702 mL
	10 mM	0.1294 mL	0.6470 mL	1.2940 mL	3.2351 mL
	15 mM	0.0863 mL	0.4313 mL	0.8627 mL	2.1567 mL
	20 mM	0.0647 mL	0.3235 mL	0.6470 mL	1.6176 mL
	25 mM	0.0518 mL	0.2588 mL	0.5176 mL	1.2940 mL
	30 mM	0.0431 mL	0.2157 mL	0.4313 mL	1.0784 mL
	40 mM	0.0324 mL	0.1618 mL	0.3235 mL	0.8088 mL
	50 mM	0.0259 mL	0.1294 mL	0.2588 mL	0.6470 mL
	60 mM	0.0216 mL	0.1078 mL	0.2157 mL	0.5392 mL
	80 mM	0.0162 mL	0.0809 mL	0.1618 mL	0.4044 mL
	100 mM	0.0129 mL	0.0647 mL	0.1294 mL	0.3235 mL

MC-VC-PAB-NH2 TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-VC-PAB-NH21616727-21-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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