MC-VC-PABC-Aur0101

Name: MC-VC-PABC-Aur0101
Brand: MedChemExpress
SKU: HY-128955
Rating: 4.5 (1 reviews)

Cat. No.: HY-128955 Purity: 99.66%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MC-VC-PABC-Aur0101 is a agent-linker conjugate for ADC with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the ADC linker MC-VC-PABC.

For research use only. We do not sell to patients.

MC-VC-PABC-Aur0101 Chemical Structure

CAS No. : 1438849-92-3

Size	Price	Stock	Quantity
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2150	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE MC-VC-PABC-Aur0101

•Mol Cancer Ther. 2023 Oct 2;22(10):1128-1143. [Abstract]

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Biological Activity
Purity & Documentation
References
Customer Review

Description

MC-VC-PABC-Aur0101 is a agent-linker conjugate for ADC with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the ADC linker MC-VC-PABC.

IC₅₀ & Target^[1]

Auristatin

In Vitro

MC-VC-PABC-Aur0101 is protease-cleavable^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1341.66

Formula

C₆₈H₁₀₀N₁₂O₁₄S

CAS No.

1438849-92-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@H]([C@@]3([H])N(CCC3)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC(C(C)(C)NC(OCC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)=O)=O)=O)=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (74.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7453 mL	3.7267 mL	7.4535 mL
5 mM	0.1491 mL	0.7453 mL	1.4907 mL
10 mM	0.0745 mL	0.3727 mL	0.7453 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.66%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (247 KB) HNMR (262 KB) RP-HPLC (242 KB) LCMS (128 KB)

Handling Instructions (2659 KB)

References

[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC) Current status and mapping of ADC:s in clinical programs.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7453 mL	3.7267 mL	7.4535 mL	18.6336 mL
	5 mM	0.1491 mL	0.7453 mL	1.4907 mL	3.7267 mL
	10 mM	0.0745 mL	0.3727 mL	0.7453 mL	1.8634 mL
	15 mM	0.0497 mL	0.2484 mL	0.4969 mL	1.2422 mL
	20 mM	0.0373 mL	0.1863 mL	0.3727 mL	0.9317 mL
	25 mM	0.0298 mL	0.1491 mL	0.2981 mL	0.7453 mL
	30 mM	0.0248 mL	0.1242 mL	0.2484 mL	0.6211 mL
	40 mM	0.0186 mL	0.0932 mL	0.1863 mL	0.4658 mL
	50 mM	0.0149 mL	0.0745 mL	0.1491 mL	0.3727 mL
	60 mM	0.0124 mL	0.0621 mL	0.1242 mL	0.3106 mL