2. Academic Validation
  3. New isomalabaricane triterpenes from the marine sponge Stelletta globostellata that induce morphological changes in rat fibroblasts

New isomalabaricane triterpenes from the marine sponge Stelletta globostellata that induce morphological changes in rat fibroblasts

  • J Nat Prod. 2000 Feb;63(2):205-9. doi: 10.1021/np990333d.
N Oku 1,  S Matsunaga,  S i Wada,  S Watabe,  N Fusetani
Affiliations

Affiliation

  • 1 Laboratory of Aquatic Natural Products Chemistry and Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
PMID: 10691710 DOI: 10.1021/np990333d
Abstract

Three new isomalabaricane Triterpenes, 29-hydroxystelliferin D (2), 3-epi-29-hydroxystelliferin E (3), and 3-epi-29-hydroxystelliferin A (4), were isolated from the marine Sponge Stelletta globostellata. Their structures, including absolute stereochemistry, were determined on the basis of spectral data and chemical methods. Rat fibroblasts treated with 0.2 microM of 2-4 exhibited unusual morphological characteristics, followed by death in 5 days.

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