2. Academic Validation
  3. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

  • Science. 2001 Sep 14;293(5537):2108-11. doi: 10.1126/science.1061965.
J S Thompson 1,  S A Bixler,  F Qian,  K Vora,  M L Scott,  T G Cachero,  C Hession,  P Schneider,  I D Sizing,  C Mullen,  K Strauch,  M Zafari,  C D Benjamin,  J Tschopp,  J L Browning,  C Ambrose
Affiliations

Affiliation

  • 1 Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA., The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.
PMID: 11509692 DOI: 10.1126/science.1061965
Abstract

B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.

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