2. Academic Validation
  3. Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

  • J Nat Prod. 2002 Feb;65(2):210-4. doi: 10.1021/np0104020.
Deniz Tasdemir 1,  Gina C Mangalindan,  Gisela P Concepción,  Sheryl M Verbitski,  Sridhar Rabindran,  Miriam Miranda,  Michael Greenstein,  John N A Hooper,  Mary Kay Harper,  Chris M Ireland
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
PMID: 11858759 DOI: 10.1021/np0104020
Abstract

Two new isomalabaricane Triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine Sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively.

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