1. Academic Validation
  2. Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa

Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa

  • J Nat Prod. 2002 May;65(5):776-8. doi: 10.1021/np010581l.
Leng Chee Chang 1 Sarah Otero-Quintero John N A Hooper Carole A Bewley
Affiliations

Affiliation

  • 1 Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0820, USA.
Abstract

Two new pyrroloquinoline Alkaloids, isobatzelline E (1) and batzelline D (2), together with the known compounds batzelline C (3), isobatzelline C (4), and makaluvamine D (5), were isolated from an Indopacific collection of the marine Sponge Zyzzya fuliginosa; the known compounds makaluvamines A (9), H (10), J (7), K (8), and P (6) were obtained from Z. fuliginosa collected in Papua New Guinea. The structures were elucidated by interpretation of 1D (1)H and (13)C NMR spectra and 2D HSQC and HSQC-LR spectra. Compounds 1-10 were isolated because the crude extracts of both Zyzzya species inhibited HIV-1 envelope-mediated cell fusion. However, the inhibition profile observed for the pure compounds 1-10 mirrors that reported for the inhibition of Topoisomerase II by Other pyrroloquinolines, leaving open the possibility that the activity results from interactions with DNA-modifying Enzymes.

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