2. Academic Validation
  3. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone

Trypsin inhibitory effect of wedelolactone and demethylwedelolactone

  • Phytother Res. 2003 Apr;17(4):420-1. doi: 10.1002/ptr.1153.
Samiulla D Syed 1,  Mundkinajeddu Deepak,  Shivanna Yogisha,  Arun P Chandrashekar,  Keerthi A Muddarachappa,  Prashanth D'Souza,  Amit Agarwal,  B V Venkataraman
Affiliations

Affiliation

  • 1 Bioassay Unit, R&D Centre, Natural Remedies Pvt Ltd, 5B, Veerasandra Indl Area, Hosur Road, Bangalore 561 229, India.
PMID: 12722155 DOI: 10.1002/ptr.1153
Abstract

Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.

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