2. Academic Validation
  3. L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

  • Eur J Pharmacol. 1992 Nov 2;227(3):361-2. doi: 10.1016/0922-4106(92)90018-q.
C Thomsen 1,  P Kristensen,  E Mulvihill,  B Haldeman,  P D Suzdak
Affiliations

Affiliation

  • 1 Department of Receptor Neurochemistry, CNS Discovery, Novo Nordisk Park, Måløv, Denmark.
PMID: 1361913 DOI: 10.1016/0922-4106(92)90018-q
Abstract

Glutamate and L-AP4 inhibited forskolin-stimulated cyclic AMP (cAMP) production in baby hamster kidney (BHK) cells transfected with the type IV metabotropic receptor (mGluR4). In situ hybridization revealed a high level of mRNA for the mGluR4 in the entorhinal cortex, but not in the dentate gyrus. These data demonstrate that mGluR4 receptors are negatively coupled to the cAMP cascade, and suggest that the mGluR4 receptor may be the previously described presynaptic L-AP4 receptor.

Figures
Products