2. Academic Validation
  3. Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide

Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide

  • J Nat Prod. 2003 Nov;66(11):1441-6. doi: 10.1021/np030262p.
Khanit Suwanborirux 1,  Surattana Amnuoypol,  Anuchit Plubrukarn,  Sunibhond Pummangura,  Akinori Kubo,  Chieko Tanaka,  Naoki Saito
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
PMID: 14640515 DOI: 10.1021/np030262p
Abstract

Renieramycins M (1m) and N (1n) were isolated from the Thai Sponge Xestospongia sp., pretreated with potassium cyanide in methanolic buffer solution, and their structures and relative stereochemistries were elucidated on the basis of spectroscopic data. This strategy is the first example of the gram-scale preparation of this series of compounds and presents a potential solution for increasing the gram-scale supply of novel Natural Products from marine sources.

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