2. Academic Validation
  3. Synthesis of new 3-arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity

Synthesis of new 3-arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity

  • Bioorg Med Chem Lett. 2003 Dec 15;13(24):4451-4. doi: 10.1016/j.bmcl.2003.09.001.
Won-Jea Cho 1,  Sun Young Min,  Thanh Nguyen Le,  Tae Sung Kim
Affiliations

Affiliation

  • 1 College of Pharmacy, Chonnam National University, Yong-Bong dong, Buk-gu, Kwangju 500-757, South Korea. wjcho@chonman.ac.kr
PMID: 14643344 DOI: 10.1016/j.bmcl.2003.09.001
Abstract

To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent Topoisomerase I inhibitory activity. Docking study of 7d with Topoisomerase I-DNA complex was also performed.

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