2. Academic Validation
  3. Update on the mechanism of action of bimatoprost: a review and discussion of new evidence

Update on the mechanism of action of bimatoprost: a review and discussion of new evidence

  • Surv Ophthalmol. 2004 Mar;49 Suppl 1:S5-11. doi: 10.1016/j.survophthal.2003.12.014.
Achim H-P Krauss 1,  David F Woodward
Affiliations

Affiliation

  • 1 Allergan, Inc, Irvine, California 92612-1531, USA.
PMID: 15016556 DOI: 10.1016/j.survophthal.2003.12.014
Abstract

Bimatoprost is a pharmacologically unique and highly efficacious anti-glaucoma agent. It appears to mimic the activity of the prostamides, which are biosynthesized from the natural endocannabinoid anandamide by the Enzyme cyclo-oxygenase 2 (COX-2). Bimatoprost has also been suggested to lower intraocular pressure by behaving as a prodrug or, alternatively, by stimulating FP receptors directly. These three distinctly different hypotheses for the mechanism of bimatoprost activity are discussed in the light of current evidence.

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