2. Academic Validation
  3. Harmane induces anxiolysis and antidepressant-like effects in rats

Harmane induces anxiolysis and antidepressant-like effects in rats

  • Ann N Y Acad Sci. 2003 Dec:1009:196-201. doi: 10.1196/annals.1304.024.
Feyza Aricioglu 1,  Hale Altunbas
Affiliations

Affiliation

  • 1 Department of Pharmacology, Faculty of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey. feyzak@turk.net
PMID: 15028588 DOI: 10.1196/annals.1304.024
Abstract

A forced swim test (FST) and an elevated plus maze (EPM) were used to determine antidepressant and anxiolytic effects of harmane in rats in comparison with a known antidepressant, imipramine (30 mg/kg i.p.). Harmane (2.5, 5.0, or 10 mg/kg, i.p.), saline, or imipramine were given 30 minutes before the tests. Administration of harmane decreased the time of immobility in the FST dose-dependently and increased the time spent in open arms in the EPM, as compared with the saline group. As an endogenous substance, harmane therefore has anti-anxiety and antidepressant effects.

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