2. Academic Validation
  3. Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert

Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert

  • J Nat Prod. 2004 Mar;67(3):328-32. doi: 10.1021/np030353m.
Guang-Xiong Zhou 1,  E M Kithsiri Wijeratne,  Donna Bigelow,  Leland S Pierson 3rd,  Hans D VanEtten,  A A Leslie Gunatilaka
Affiliations

Affiliation

  • 1 SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA.
PMID: 15043404 DOI: 10.1021/np030353m
Abstract

Bioassay-guided fractionation of a cytotoxic EtOAc extract of Aspergillus flavipes occurring in the rhizosphere of Ericameria laricifolia resulted in the isolation of three new cytochalasans, namely, aspochalasins I (1), J (2), and K (3), and four known cytochalasans, aspochalasins C (4), D (5), and E (6) and TMC-169 (7). The structures of compounds 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic analysis. All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 Cancer cell lines, but none showed significant selectivity.

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