2. Academic Validation
  3. Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)

  • Biochim Biophys Acta. 2004 Oct 11;1665(1-2):1-5. doi: 10.1016/j.bbamem.2004.07.006.
Dorte Strøbaek 1,  Lene Teuber,  Tino D Jørgensen,  Philip K Ahring,  Katrine Kjaer,  Rie S Hansen,  Søren Peter Olesen,  Palle Christophersen,  Bo Skaaning-Jensen
Affiliations

Affiliation

  • 1 NeuroSearch A/S, Pederstrupvej 93, DK-2750 Ballerup, Denmark.
PMID: 15471565 DOI: 10.1016/j.bbamem.2004.07.006
Abstract

We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously been reported to be activated by the benzimidazolinone, 1-EBIO and more potently by its dichloronated-analogue, DC-EBIO. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell.

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