2. Academic Validation
  3. Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta

Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta

  • J Nat Prod. 2004 Dec;67(12):2033-6. doi: 10.1021/np040145+.
Fang Lv 1,  Zhiwei Deng,  Jun Li,  Hongzheng Fu,  Rob W M van Soest,  Peter Proksch,  Wenhan Lin
Affiliations

Affiliation

  • 1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
PMID: 15620246 DOI: 10.1021/np040145+
Abstract

Fractionation of the marine Sponge Rhabdastrella aff. distincta led to the isolation and characterization of four new isomalabaricane analogues, isogeoditin A (1), 13-(E)-isogeoditin A (2), isogeoditin B (3), and 22,23-dihydrostellettin B (4), along with seven known isomalabaricane derivatives (5-11). Methylation of 10 and 11 afforded methyl esters 12 and 13. The structures of compounds 1-4 were determined on the basis of spectroscopic data analysis. All compounds were tested against a small panel of human tumor cell lines.

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