2. Academic Validation
  3. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells

Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells

  • Cancer Lett. 1992 Apr 15;63(2):125-33. doi: 10.1016/0304-3835(92)90062-z.
T D Shultz 1,  B P Chew,  W R Seaman,  L O Luedecke
Affiliations

Affiliation

  • 1 Department of Food Science and Human Nutrition, Washington State University, Pullman 99164-6376.
PMID: 1562989 DOI: 10.1016/0304-3835(92)90062-z
Abstract

The effects of physiologic concentrations of conjugated linoleic acid (CLA) and beta-carotene were assessed on human (M21-HPB, malignant melanoma; HT-29, colorectal; MCF-7, breast) Cancer cells. The incubation of Cancer cells with CLA showed significant reductions in proliferation (18-100%) compared to control cultures. M21-HPB and MCF-7 cell mortality was dose- and time-dependent. beta-Carotene was inhibitory to breast cells only. MCF-7 cells supplemented with CLA incorporated significantly less [3H]leucine (45%), [3H]uridine (63%) and [3H]thymidine (46%) than control cultures. M21-HPB and HT-29 cells supplemented with CLA incorporated less [3H]leucine (25-30%). These in vitro results suggest that CLA and beta-carotene may be cytotoxic to human Cancer cells in vivo.

Figures
Products