1. Academic Validation
  2. Skeleton-selective fluorescent chemosensor based on cyclodextrin bearing a 4-amino-7-nitrobenz-2-oxa-1,3-diazole moiety

Skeleton-selective fluorescent chemosensor based on cyclodextrin bearing a 4-amino-7-nitrobenz-2-oxa-1,3-diazole moiety

  • Org Biomol Chem. 2005 Dec 7;3(23):4262-7. doi: 10.1039/b508477f.
Hiroshi Ikeda 1 Takuya Murayama Akihiko Ueno
Affiliations

Affiliation

  • 1 Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B44 Nagatsuta-cho, Midori-ku, Yokohama, 226-8501. Japan. hikeda@bio.titech.ac.jp
Abstract

A new type of fluorescent chemosensor, based on modified cyclodextrins bearing the fluorophore unit NBD-amine, was prepared. One of these new chemosensors, NC0betaCD, is sensitive to adamantane and borneol derivatives, which have a comparatively spherical shape that fits the beta-CD cavity, but is not sensitive to bile acids, which are strongly bound by the native beta-CD. Even in the presence of a bile acid, NC0betaCD can detect 1-adamantanol. Another of this new type of chemosensors, NC0gammaCD, is sensitive to bile acids but not to adamantane derivatives. The response of the new type of chemosensors to a guest was an increase in the fluorescence intensity.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-119791
    Fluorogenic Amine