2. Academic Validation
  3. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

  • Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. doi: 10.1016/j.bmcl.2006.03.020.
Jay P Powers 1,  Shyun Li,  Juan C Jaen,  Jinqian Liu,  Nigel P C Walker,  Zhulun Wang,  Holger Wesche
Affiliations

Affiliation

  • 1 Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA. jppowers@amgen.com
PMID: 16563752 DOI: 10.1016/j.bmcl.2006.03.020
Abstract

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.

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