2. Academic Validation
  3. Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors

  • Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. doi: 10.1016/j.bmcl.2006.05.019.
Chamakura V N S Varaprasad 1,  Dinesh Barawkar,  Hassan El Abdellaoui,  Subrata Chakravarty,  Matthew Allan,  Huanming Chen,  Weijian Zhang,  Jim Z Wu,  Robert Tam,  Robert Hamatake,  Stanley Lang,  Zhi Hong
Affiliations

Affiliation

  • 1 Drug Discovery, Valeant Pharmaceutical Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com
PMID: 16725322 DOI: 10.1016/j.bmcl.2006.05.019
Abstract

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.

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