2. Academic Validation
  3. A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

  • Chem Biodivers. 2006 Jan;3(1):101-5. doi: 10.1002/cbdv.200690000.
Quan-Bin Han 1,  Ling Yang,  Yu-Lin Wang,  Chun-Feng Qiao,  Jing-Zheng Song,  Han-Dong Sun,  Hong-Xi Xu
Affiliations

Affiliation

  • 1 Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
PMID: 17193222 DOI: 10.1002/cbdv.200690000
Abstract

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

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