2. Academic Validation
  3. Oxazolidinones as novel human CCR8 antagonists

Oxazolidinones as novel human CCR8 antagonists

  • Bioorg Med Chem Lett. 2007 Mar 15;17(6):1722-5. doi: 10.1016/j.bmcl.2006.12.076.
Jian Jin 1,  Yonghui Wang,  Feng Wang,  Jeffery K Kerns,  Victoria M Vinader,  Ashley P Hancock,  Matthew J Lindon,  Graeme I Stevenson,  Dwight M Morrow,  Parvathi Rao,  Cuc Nguyen,  Victoria J Barrett,  Chris Browning,  Guido Hartmann,  David P Andrew,  Henry M Sarau,  James J Foley,  Anthony J Jurewicz,  James A Fornwald,  Andy J Harker,  Michael L Moore,  Ralph A Rivero,  Kristen E Belmonte,  Helen E Connor
Affiliations

Affiliation

  • 1 Discovery Medicinal Chemistry, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. jian.jin@gsk.com
PMID: 17267215 DOI: 10.1016/j.bmcl.2006.12.076
Abstract

High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.

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