1. Academic Validation
  2. Oxazolidinones as novel human CCR8 antagonists

Oxazolidinones as novel human CCR8 antagonists

  • Bioorg Med Chem Lett. 2007 Mar 15;17(6):1722-5. doi: 10.1016/j.bmcl.2006.12.076.
Jian Jin 1 Yonghui Wang Feng Wang Jeffery K Kerns Victoria M Vinader Ashley P Hancock Matthew J Lindon Graeme I Stevenson Dwight M Morrow Parvathi Rao Cuc Nguyen Victoria J Barrett Chris Browning Guido Hartmann David P Andrew Henry M Sarau James J Foley Anthony J Jurewicz James A Fornwald Andy J Harker Michael L Moore Ralph A Rivero Kristen E Belmonte Helen E Connor
Affiliations

Affiliation

  • 1 Discovery Medicinal Chemistry, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. jian.jin@gsk.com
Abstract

High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.

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