2. Academic Validation
  3. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

  • Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65. doi: 10.1016/j.bmcl.2006.11.056.
Ke Wang 1,  Jinfeng Li,  Alexei Degterev,  Emily Hsu,  Junying Yuan,  Chengye Yuan
Affiliations

Affiliation

  • 1 State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
PMID: 17270434 DOI: 10.1016/j.bmcl.2006.11.056
Abstract

Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of Necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure-activity relationship (SAR) of Nec-5 series in inhibiting Necroptosis.

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