2. Academic Validation
  3. Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: synthesis and biological evaluation

Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: synthesis and biological evaluation

  • Bioorg Med Chem Lett. 2007 Apr 15;17(8):2166-70. doi: 10.1016/j.bmcl.2007.02.015.
Hong Yin 1,  Yufang Xu,  Xuhong Qian,  Yuanli Li,  Jianwen Liu
Affiliations

Affiliation

  • 1 Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
PMID: 17331719 DOI: 10.1016/j.bmcl.2007.02.015
Abstract

Novel tertiary amine N-oxides of naphthalimides were designed and synthesized as potential Anticancer agents against hypoxic solid tumors. Although their ctDNA-binding affinities and cytotoxic activities against usual tumor cell lines were lower than those of corresponding amines, the N-oxides A1 and A4 showed hypoxia preference activities against A375 cells in vitro and might be used as interesting candidates of prodrug leads in hypoxic tumor cells.

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