2. Academic Validation
  3. Anti-inflammatory activity profile of JANEX-1 in preclinical animal models

Anti-inflammatory activity profile of JANEX-1 in preclinical animal models

  • Bioorg Med Chem. 2008 Feb 1;16(3):1287-98. doi: 10.1016/j.bmc.2007.10.066.
Fatih M Uckun 1,  Heather Tibbles,  Zahide Ozer,  Sanjive Qazi,  Alexei Vassilev
Affiliations

Affiliation

  • 1 Parker Hughes Cancer Center, 2848 Patton Road, St. Paul, MN 55113, USA. fatih_uckun@ih.org
PMID: 18024136 DOI: 10.1016/j.bmc.2007.10.066
Abstract

We examined the biologic activity of the rationally designed JAK3 Inhibitor, JANEX-1, in several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-inflammatory activity in each of these preclinical models, including mouse models of peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore, JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study may provide the basis for new and effective treatment as well as prevention programs for inflammatory disorders.

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