Evaluation of anti-inflammatory and antioxidant activities of copper (II) Schiff mono-base and copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole

Highly reactive radicals are implicated in many pathological conditions. The quest for radical scavengers or Antioxidants, spans the previous decades. A new series of complexes of the type [Cu (dien) (2a-2tzn) Y(2)] and [Cu (dienXXY(2)) (2a-5mt)] and of the type [Cu (dptaS) Cl(2)] and [Cu (dptaS) Br(2)] (dptaS = 1, 3-propanediamine) or Schiff mono-base of dipropylenetriamine with 2-thiophene-carboxaldehyde, has been tested for anti-inflammatory and antioxidant activity. The tested compounds inhibit the carrageenin-induced rat paw edema (52.0-82.6%) and present important scavenging activity. Compound 6 is the most potent (82.6%) in the in vivo experiment. Lipophilicity-as R(M) values - has been determined. The results support that in general, adducts of the type [Cu (dienXXY(2)) (2a-5mt)] exhibit increased activity compared to the starting material of type [Cu (dienXXY(2))]. An attempt to correlate the biological results with their structural characteristics and physicochemical parameters has been made.