2. Academic Validation
  3. Synthesis and antitumor activity of novel amsacrine analogs: the critical role of the acridine moiety in determining their biological activity

Synthesis and antitumor activity of novel amsacrine analogs: the critical role of the acridine moiety in determining their biological activity

  • Bioorg Med Chem. 2009 Jan 15;17(2):523-9. doi: 10.1016/j.bmc.2008.11.072.
Adriana Chilin 1,  Giovanni Marzaro,  Christine Marzano,  Lisa Dalla Via,  Maria Grazia Ferlin,  Giovanni Pastorini,  Adriano Guiotto
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy. adriana.chilin@unipd.it
PMID: 19101158 DOI: 10.1016/j.bmc.2008.11.072
Abstract

A new series of N-[4-(2'-oxo-2H-pyrano[2,3-b]quinolin-5'-ylamino)-phenyl]-methanesulfonamides was prepared and analyzed as novel amsacrine-like derivatives. Our preliminary biological evaluation has shown that the replacement of the acridine moiety with the analogous 2-oxo-2H-pyrano[2,3-b]quinoline system drastically reduced both their Anticancer activity and their propency to intercalate into double stranded DNA.

Figures