2. Academic Validation
  3. Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

  • Angew Chem Int Ed Engl. 2009;48(9):1629-32. doi: 10.1002/anie.200805529.
Ulrik Hillaert 1,  Martijn Verdoes,  Bogdan I Florea,  Athanasios Saragliadis,  Kim L L Habets,  Johan Kuiper,  Serge Van Calenbergh,  Ferry Ossendorp,  Gijsbert A van der Marel,  Christoph Driessen,  Hermen S Overkleeft
Affiliations

Affiliation

  • 1 Leiden Institute of Chemistry, Leiden University, P.O. Box 9052, 2300 RA Leiden, The Netherlands.
PMID: 19156780 DOI: 10.1002/anie.200805529
Abstract

Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-101779
    Cysteine Cathepsins Probe