2. Academic Validation
  3. C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties

C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties

  • Bioorg Med Chem Lett. 2009 Aug 15;19(16):4584-8. doi: 10.1016/j.bmcl.2009.06.097.
Huu Tung Nguyen 1,  Van Minh Chau,  Thu Ha Tran,  Van Kiem Phan,  Thanh Huong Hoang,  Tien Dat Nguyen,  Xuan Nhiem Nguyen,  Bui Huu Tai,  Jae-Hee Hyun,  Hee-Kyoung Kang,  Young Ho Kim
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
PMID: 19615900 DOI: 10.1016/j.bmcl.2009.06.097
Abstract

Two new C(29) sterols with a cyclopropane ring at C-25 and C-26, petrosterol-3,6-dione (1) and 5alpha,6alpha-epoxy-petrosterol (2), along with petrosterol (3), were isolated from the Vietnamese marine Sponge Ianthella sp. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compounds 1-3 showed cytotoxic activities on A549, HL-60, MCF-7, SK-OV-3, and U937 Cancer cell lines with IC(50) in the range of 8.4-22.6 microM, whereas compounds 1-3 exhibited only weak cytotoxic activities on HT-29 cell. After HL-60 cells were treated with the compounds, several Apoptosis events like chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. These data supported that the compounds might have potential for leukemia treatment.

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