2. Academic Validation
  3. Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)

Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)

  • Bioorg Med Chem Lett. 2009 Sep 15;19(18):5289-92. doi: 10.1016/j.bmcl.2009.07.148.
John F Mehlmann 1,  Matthew L Crawley,  Joseph T Lundquist 4th,  Ray J Unwalla,  Douglas C Harnish,  Mark J Evans,  Callain Y Kim,  Jay E Wrobel,  Paige E Mahaney
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
PMID: 19683924 DOI: 10.1016/j.bmcl.2009.07.148
Abstract

Pyrrole[2,3-d]azepines have been identified as potent agonists of the farnesoid X receptor (FXR). Based on the planar X-ray crystal structure of WAY-362450 1 in the ligand binding domain and molecular modeling studies, non-planar reduced compounds were designed which led to agonists that exhibit high aqueous solubility and retain moderate in vitro potency.

Figures