2. Academic Validation
  3. Sesquiterpenoids and benzofuranoids from the marine-derived fungus Aspergillus ustus 094102

Sesquiterpenoids and benzofuranoids from the marine-derived fungus Aspergillus ustus 094102

  • J Nat Prod. 2009 Oct;72(10):1761-7. doi: 10.1021/np900268z.
Zhenyu Lu 1,  Yi Wang,  Chengdu Miao,  Peipei Liu,  Kui Hong,  Weiming Zhu
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
PMID: 19769341 DOI: 10.1021/np900268z
Abstract

Eight drimane Sesquiterpenes (1-8), six isochromane derivatives (9-14), and three known compounds, daldinin B (15), 9alpha-hydroxy-6beta-[(2E,4E,6E)-octa-2,4,6-trienoyloxy]-5alpha-drim-7-en-11,12-olide (16), and pergillin (17), were isolated from the EtOAc extract of the marine-derived fungus Aspergillus ustus 094102. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxic effects on A549 and HL-60 cell lines were evaluated by SRB and MTT methods. Ustusorane E (13) showed significant cytotoxicity against HL-60 cells with an IC50 value of 0.13 microM. Ustusolates C (6) and E (8) exhibited moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively, and ustusolate A (4) showed weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.

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