2. Academic Validation
  3. Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

  • J Nat Prod. 2009 Sep;72(9):1585-8. doi: 10.1021/np900220r.
Hongbing Liu 1,  RuAngelie Edrada-Ebel,  Rainer Ebel,  Yao Wang,  Barbara Schulz,  Siegfried Draeger,  Werner E G Müller,  Victor Wray,  Wenhan Lin,  Peter Proksch
Affiliations

Affiliation

  • 1 Institut fur Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universitat Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany.
PMID: 19778087 DOI: 10.1021/np900220r
Abstract

Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine Sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC(50) against L5178Y cell line: 0.6 microg/mL).

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