2. Academic Validation
  3. 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

  • Bioorg Med Chem Lett. 2010 Jan 1;20(1):42-7. doi: 10.1016/j.bmcl.2009.11.041.
Arjun Basnet 1,  Pritam Thapa,  Radha Karki,  Hoyoung Choi,  Jae Hun Choi,  Minho Yun,  Byeong-Seon Jeong,  Yurngdong Jahng,  Younghwa Na,  Won-Jea Cho,  Youngjoo Kwon,  Chong-Soon Lee,  Eung-Seok Lee
Affiliations

Affiliation

  • 1 College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.
PMID: 19954977 DOI: 10.1016/j.bmcl.2009.11.041
Abstract

For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their Topoisomerase I and II inhibitory activity as well as cytotoxicity against several human Cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong Topoisomerase I inhibitory activity. In addition, a docking study with Topoisomerase I and compound 24 was performed.

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