2. Academic Validation
  3. Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists

Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists

  • Bioorg Med Chem Lett. 2010 Apr 1;20(7):2099-102. doi: 10.1016/j.bmcl.2010.02.072.
Jee Woong Lim 1,  Youna Oh,  Jong-Hoon Kim,  Min-Ho Oak,  Yongho Na,  Jung-Ok Lee,  Seung-Woo Lee,  Heeyeong Cho,  Woo-Kyu Park,  Gildon Choi,  Jongmin Kang
Affiliations

Affiliation

  • 1 Yangji Chemicals, Gyeonggi Bio-Center, Suwon 443-766, Republic of Korea. srhnys@hwpharm.com
PMID: 20223662 DOI: 10.1016/j.bmcl.2010.02.072
Abstract

Novel 3-aminopyrrolidine derivatives were synthesized and evaluated for their antagonistic activity against human Chemokine Receptor 2. Structure-activity studies on 3-aminopyrrolidine incorporating heteroatomic carbocycle moieties led to piperidine compound 19, and piperazine compounds 42, 47 and 49 as highly potent hCCR2 antagonists.

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