1. Academic Validation
  2. Dioxamycin, a new benz[a]anthraquinone antibiotic

Dioxamycin, a new benz[a]anthraquinone antibiotic

  • J Antibiot (Tokyo). 1991 Apr;44(4):396-402. doi: 10.7164/antibiotics.44.396.
R Sawa 1 N Matsuda T Uchida T Ikeda T Sawa H Naganawa M Hamada T Takeuchi
Affiliations

Affiliation

  • 1 Institute of Microbial Chemistry, Tokyo, Japan.
Abstract

A new Antibiotic, dioxamycin (1) was isolated from the culture broth of the strain MH406-SF1, which was closely related to Streptomyces xantholiticus. This Antibiotic was purified by countercurrent chromatography, column chromatography and preparative HPLC. The molecular formula of 1 was determined to be C38H40O15 by HRFAB-MS. The structure was determined by spectral analysis of 2D NMR; 1H-1H COSY, 13C-1H COSY, long range 13C-1H COSY (HMBC) and NOESY. The Antibiotic is active in vitro against Gram-positive bacteria and some tumor cells. Dioxamycin is a benz[a]anthraquinone Antibiotic related to capoamycin.

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