2. Academic Validation
  3. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava

Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava

  • Org Lett. 2010 Nov 5;12(21):5040-3. doi: 10.1021/ol102179u.
Meng Shao 1,  Ying Wang,  Zhong Liu,  Dong-Mei Zhang,  Hui-Hui Cao,  Ren-Wang Jiang,  Chun-Lin Fan,  Xiao-Qi Zhang,  He-Ru Chen,  Xin-Sheng Yao,  Wen-Cai Ye
Affiliations

Affiliation

  • 1 Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
PMID: 20929258 DOI: 10.1021/ol102179u
Abstract

Psiguadials A (1) and B (2), two novel sesquiterpenoid-diphenylmethane meroterpenoids with unusual skeletons, along with a pair of known epimers, psidial A (3) and guajadial (4), were isolated from the leaves of Psidium guajava. Their structures with absolute configurations were elucidated by means of NMR, X-ray diffraction, and quantum chemical CD calculation. Compounds 1, 2, and 4 exhibited potent inhibitory effects on the growth of human hepatoma cells.

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