Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities

J Nat Prod. 2010 Nov 29;73(11):1914-21. doi: 10.1021/np100583u.

Sheng Lin ¹, Yanling Zhang, Mingtao Liu, Sen Yang, Maoluo Gan, Jiachen Zi, Weixia Song, Xiaona Fan, Sujuan Wang, Yang Liu, Yongchun Yang, Xiaoguang Chen, Ying Guo, Wenjie Wang, Jiangong Shi

Affiliations

Affiliation

1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China.

PMID: 20961093 DOI: 10.1021/np100583u

Abstract

Fourteen new abietane (1-14) and seven new C(20)-norabietane (15-21) diterpenes, together with five known analogues, have been isolated from the stem bark of Fraxinus sieboldiana. Their structures were elucidated by spectroscopic data analysis. In the in vitro assays, at 10(-5) M, compounds 8, 16, and 22 showed inhibitory activity against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with 59.7 ± 4.8%, 56.1 ± 5.6%, and 65.9 ± 3.1% inhibition, respectively. Compound 23 was active against H5N1 avian Influenza Virus with an IC(50) value of 4.8 μM. Compounds 3 and 5 exhibited selective cytotoxic activities against A2780 (IC(50) 1.7 μM) and A549 (IC(50) 6.0 μM), respectively.

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