2. Academic Validation
  3. Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone

Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone

  • J Org Chem. 2011 Feb 4;76(3):963-6. doi: 10.1021/jo101782q.
Atul K Hajare 1,  Velayutham Ravikumar,  Shaik Khaleel,  Debnath Bhuniya,  D Srinivasa Reddy
Affiliations

Affiliation

  • 1 Advinus Therapeutics Ltd., Pune, India.
PMID: 21192736 DOI: 10.1021/jo101782q
Abstract

An efficient synthesis of potent molluscicidal agent cyanolide A, a glycosidic 16-membered Macrolide, starting from D-(-)-pantolactone is reported. Highly stereoselective aldol, oxa-Michael addition, and Yamaguchi macrolactonization are the key steps in the present synthesis.

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