2. Academic Validation
  3. Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5

Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5

  • Bioorg Med Chem. 2011 Feb 1;19(3):1256-63. doi: 10.1016/j.bmc.2010.12.031.
Hardik S Bodiwala 1,  Sudeep Sabde,  Pawan Gupta,  Ruchira Mukherjee,  Rajender Kumar,  Prabha Garg,  Kamlesh Kumar Bhutani,  Debashis Mitra,  Inder Pal Singh
Affiliations

Affiliation

  • 1 Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab 160 062, India.
PMID: 21227704 DOI: 10.1016/j.bmc.2010.12.031
Abstract

Designing multi-functional ligands is a recent strategy by which multiple targets can be inhibited by a single entity. A series of caffeoyl-anilide compounds based on structures of various integrase and CCR-5 inhibitors have been designed and synthesized as anti-HIV agents in the present study. Most of the compounds exhibited potent anti-HIV activity at micromolar concentration in CEM-GFP CD4+ T cells infected with HIV-1NL4.3 virus. Compound 14 showed a lower EC(50) and better TI as compared to AZT. Mechanism based studies suggest that these compounds inhibit either one or in some cases, both the targets. The experimental data and the docking results showed that these compounds are potential inhibitors for both HIV-1 IN and CCR5.

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