1. Academic Validation
  2. Chemical constituents of Talauma arcabucoana (Magnoliaceae): their brine shrimp lethality and antimicrobial activity

Chemical constituents of Talauma arcabucoana (Magnoliaceae): their brine shrimp lethality and antimicrobial activity

  • Nat Prod Res. 2011 Sep;25(16):1497-504. doi: 10.1080/14786410903205146.
John Alexander Corredor Barinas 1 Luis Enrique Cuca Suárez
Affiliations

Affiliation

  • 1 Laboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 # 45-03, Bogotá, DC, Colombia.
Abstract

A new aporphine alkaloid, (-)-arcabucoine [(6aR)-N-formyl-1,2-methylenedioxy-9,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline] 1 was isolated from the leaves of Talauma arcabucoana (Magnoliaceae), along with the known compounds (-)-erythro-saccharinic acid lactone 2 and (-)-shikimic acid 3. Furthermore, the known Aporphine Alkaloids (-)-dicentrine 4, (-)-nordicentrine 5 and dicentrinone 6 were isolated from the stem bark. The Alkaloids 4 and 5 were found to be the most active compounds in a brine shrimp lethality assay. In addition, Alkaloids 1, 4 and 5 showed moderate growth inhibition against Staphylococcus aureus and Candida albicans.

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