2. Academic Validation
  3. Kabiramides J and K, trisoxazole macrolides from the sponge Pachastrissa nux

Kabiramides J and K, trisoxazole macrolides from the sponge Pachastrissa nux

  • J Nat Prod. 2011 May 27;74(5):1288-92. doi: 10.1021/np100886y.
Thanchanok Sirirak 1,  Siriporn Kittiwisut,  Chittrawan Janma,  Supreeya Yuenyongsawad,  Khanit Suwanborirux,  Anuchit Plubrukarn
Affiliations

Affiliation

  • 1 Marine Natural Products Research Unit (MNP), Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
PMID: 21410162 DOI: 10.1021/np100886y
Abstract

Three trisoxazole macrolides possessing a 30-α,β-enone moiety, including the known kabiramide G (1) and the new kabiramides J (2) and K (3), were isolated from the Sponge Pachastrissa nux, along with the previously reported kabiramides B (4), C (5), and D (6). To date, the enone moiety has been found to associate solely with the trisoxazole macrolides from P. nux. All of the isolated macrolides showed moderate to strong antimalarial and cytotoxic activities, except for 1, which possessed only potent cytotoxicity.

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